A Case Reporter Of Precancerous Atypical Endometrial Hyperplasia

Background: Endometrial Cancer(EC)is the three most common female of reproductiveorgan malignant tumor,about 7% of female malignant tumor,and 20% of the reproductive system tumor,It is more common in perimenopausal or menopausal women,menopausal women account for about 70%,the average age of 55,However,in recent years,endometrial cancer has become young women,nearly 25% of the patients occurre in premenopausal,of which 3% ~ 14% in before 40.Atypical Endometrial Hyperplasia(AEH)is a precancerous lesion of endometrial cancer.Early diagnosis of endometrial atypical hyperplasia plays a very important role in the prevention and treatment of endometrial cancer.In 2014,WHO Classicfication of Tumor of Female Reproductive Organ defined cytological atypia superimposed on endometrial hyperplasia but a lack of revidence of invasion.The symptoms of atypical endometrial hyperplasia are mainly menstrual abnormalities,and the diagnosis is usually confirmed by diagnosis and curettage.The feature of Atypical Endometrial Hyperplasia is abnormal menstruation,it diagnosis usually ues curettage,some patients diagnosed with endometrial cancer after hysterectomy.Therefore,how to accurately diagnose and treat endometrium cancer in clinical plays an important role in women with fertility preservation.Objective: To describe the characteristics of atypical endometrial hyperplasia through the diagnosis basis,differential diagnosis,therapy and genetic molecular of endometrial atypical hyperplasia,it provide a basis for accurate diagnosis and reduce misdiagnosis of endometrium cancer to preserve fertility.Methods: Review the diagnosis and treatment of a young endometrial atypical hyperplasia patient in our hospital in 2019 and report the clinical data of this case in detail,and make a review according to the literature over the world.Results: It is very important to distinguish atypical endometrial hyperplasia from hyperplasia without atypical,they have no obvious clinical manifestations,and their imaging examination is not conducive to the identification of them.It is also difficultto distinguish atypical endometrial hyperplasia from hyperplasia without atypical and endometrioid adenocarcinoma fromhistomorphology.However,immunohistochemistry and molecular detection can be used to assist diagnosis.The therapy of endometrial cancer is mainly surgical resection of the uterus and chemotherapy.For atypical endometrial hyperplasia,the uterus can be retained for those with fertility requirements,hormone therapy and close follow-up,the prognosis is also very good.Conclusion:atypical endometrial hyperplasia and endometrioid carcinoma have the same molecular genetic changes and are in a continuous developmental lineage.The differential diagnosis of them are complex and carefully,so accurate diagnosis plays an important role in its fertility preservation.The prognosis of is good,it is feasible for women to fertility.