Association Of SOD?TSH And ERG With Diabetic Retinopathy

Objective: To investigate the correlation between superoxide dismutase(SOD),thyrotropic hormone(TSH),electroretinogram(ERG)of diabetic retinopathy.Methods: An observational analysis was performed on 184 patients with type 2diabetes in HanDan Central Hospital from January 1,2019 to February 1,2020.According to the results of nonmydriatic fundus photography,80 patients in the non-retinopathy(NDR)group and 104 patients in the retinopathy(DR)group were divided into the non-proliferative diabetic retinopathy(74 cases,NPDR)group and the proliferative diabetic retinopathy(30 cases,PDR)group.Detailed medical history was collected for the subjects.Peripheral blood was taken in the morning of the next day after admission for examination of thyrotropic hormone,superoxide dismutase,hemoglobin A1 c and general biochemical indicators.Electroretinogram and nonmydriatic fundus photography were completed as well.Using SPSS23.0 software to compare the differences of various indicators among groups and analyze the correlation between SOD,TSH and ERG of diabetic retinopathy.Results:(1)In general,ERG score in the DR group was higher than that in the NDR group,and SOD serum level was lower than that in the NDR group,with P<0.05,indicating a statistically significant difference.(2)SOD serum level of NDR group was higher than that of NPDR group and PDR group,and P<0.05,showing statistically significant difference.There was no significant difference in SOD serum level between PDR group and NPDR group.(3)ERG score of PDR group was higher than that of NDR group and NPDR group,and P<0.05,showing statistically significant difference.There was no significant difference in ERG score between NDR group and NPDR group.(4)There was no significant difference in serum level of TSH between NDR group,NPDR group and PDR group.However,TSH was within the range of 0.65-4.64uIU/ml.When TSH deviated from this range,the prevalence of PDR was significantly higher than that of NDR and NPDR,and the difference was statistically significant with P<0.05.TSH at different levels had no significant effect on the prevalence of NDR and NPDR(P>0.05),and the difference was not statistically significant.(5)Multivariate logistic regression analysis showed that after adjusting forglycosylated hemoglobin,course of disease,high-density lipoprotein and other indicators,ERG was significantly positively correlated with diabetic retinopathy,and the OR(95%CI)and P values were 1.294(1.022-1.640),P=0.033.SOD was a protective factor for diabetic retinopathy(P<0.001).Conclusions: ERG score was positively correlated with diabetic retinopathy.The increase of ERG can indicate the increased risk of PDR.SOD was a protective factor of diabetic retinopathy,and it decreased at the early stage of DR.There was no significant correlation between TSH and diabetic retinopathy,but it was found in this study that when TSH?0.65 or ?4.64uIU/ml,compared with TSH within the range of0.65-4.64uIU/ml,the incidence of PDR significantly increased.Therefore,regular screening of SOD,TSH serum levels and ERG,dynamic observation of their fluctuation trend,if there is an abnormal timely referral to the ophthalmology diagnosis and treatment,and trial supplemented by antioxidant intervention,may play a role in delaying the progress of DR and protecting the vision of T2 DM patients to a certain extent.