Study On The Basic Characteristics And Factors Affecting Disease Progression Of HBV Infected People Of Wuwei City, Gansu Province

ObjectiveViral hepatitis B caused by hepatitis B virus is a major inflammatory disease of the liver and can cause multiple organ damage.HBV infection is one of the main causes of chronic hepatitis,liver cirrhosis and liver cancer,and China is a high endemic area of HBV.The carrying rate of hepatitis B surface antigen is 5.49%.Every year,about 263000 people die of hepatitis B-related complications such as liver cirrhosis and liver cancer caused by HBV infection,so HBV infection has become a public health problem that seriously endangers the health of our people.Wuwei City,located in Gansu Province of China,is a high incidence area of hepatitis B,where HBsAg positive rate was 6.51%.Therefore,this study takes the hepatobiliary center of Wuwei Cancer Hospital as the research site,carries on the standard epidemiological investigation and hepatitis B related laboratory test of 3043 cases of HBV infection in the first district and three counties of Wuwei city,describes the basic characteristics of HBV infection in this area,and analyzes its influencing factors,which will provide an important theoretical basis for the effective prevention and treatment of HBV in this area,which will provide an important theoretical basis for the effective prevention and treatment of HBV in this area.MethodsFrom August 2018 to October 2019,the research project was carried out through various channes in four administrative divisions of Wuwei(Liangzhou District,Gulang County,Minqin County,and Tianzhu Tibetan Autonomic County),where collecting HBV-infected people.Then a standardized epidemiological survey and hepatitis B related laboratory tests(Including hepatitis B three systems,liver function seven items,alpha-fetoprotein,HBV DNA,hepatitis C antibody,abdominal color Doppler ultrasound and FibroScan)were carried out on this population in the Gansu Wuwei Tumour Hospital.The data of this study was entered online by Equry,which was independently developed by the research group.Statistical analysis was performed using SPSS 22.0 software,and Graphpad Prism software was used for drawing.Statistical methods mainly usedχ~2 test,binary logistic regression analysis,disordered multi-class logistic regression analysis and kappa consistency test method.Results1.Basic characteristics of HBV-infected people in Wuwei City:(1)A total of 3043HBV-infected people were included in this study.HBV-infected male:female=1.42:1,with an average age of 44.75±12.7 years,mainly concentrated in the age group of 40-59 years(55.2%);occupations are mainly farmers(50.3%).(2)Unvaccinated(69.7%)and family history of hepatitis B(51.0%)are the main epidemic factors of people infected with hepatitis B virus.(3)Among HBV-infected people in Wuwei,the expression patterns of HBV-M are mainly divided into 9 categories.Main modes:1490 cases(49.0%)of“HBsAg,HBeAb,HBcAb”positive serological model,764 cases(25.1%)of“HBsAg,HBcAb”positive serological model,and 463 cases(15.2%)of“HBsAg,HBeAg,HBcAb”positive serological model.(4)HBV DNA,ALT,AST,DBIL,γ-GT,LSM value,CAP value,and abdominal color Doppler ultrasound results are all associated with the“HBsAg,HBeAb,HBcAbpositive serological model”and“HBsAg,anti-HBc positive mode”and“HBsAg,HBeAg,HBcAb positive serological model”,P<0.05。2.The results of Binary logistic regression model showed that several factors affect HBV replication:female(OR=1.41,95%CI:1.17-1.69),ALT-positive(OR=1.60,95%CI:1.32-1.95),HBeAg-positive(OR=4.40,95%CI:3.42-5.66),history of antiviral therapy(OR=0.32,95%CI:0.27-0.38).3.The results of Binary logistic regression model showed that several factors affect liver fibrosis:male(OR=2.23,95%CI:1.69-2.94),30~group(OR=1.75,95%CI:1.02-3.02),40~group(OR=2.49,95%CI:1.48-4.19),50~group(OR=3.51,95%CI:2.09-5.91),Minqin County(OR=1.89,95%CI:1.27-2.80),Having a family history of hepatitis B(OR=1.51,95%CI:1.14-1.99),history of antiviral therapy(OR=0.40,95%CI:0.31-0.52).Conclusion1.The proportion with HBV infection in Wuwei City the men is higher than the women,and the ages are concentrated in the 40-59 age group,with the largest number of farmers infected.2.The prevalent serological patterns of hepatitis B population in Wuwei area are“HBsAg,HBeAb,HBcAb positive”,“HBsAg,HBcAb positive",“HBsAg,HBeAg,HBcAb positive”3.Women,ALT-positive status,HBeAg-positive status,and no history of antiviral therapy all increase the risk of HBV DNA virus replication in HBV-infected people.4.Men,older people,people with a family history of hepatitis B,and no history of antiviral therapy will increase the risk of liver fibrosis in HBV-infected people.