Study On The Correlation Between TCM Syndrome Types And Blood Uric Acid Level With Left Ventricular Hypertrophy In Patients With Chronic Kidney Disease

Objective: In this study,TCM summarizes the distribution of TCM syndromes of Chronic kidney disease and discusses the correlation between the distribution patterns of TCM syndromes and clinical indicators.Western medicine chose to retrospectively analyze the effect of blood uric acid level on left ventricular mass fraction in patients with chronic kidney disease without dialysis,so as to further study the effect of SUA on left ventricular hypertrophy and finally discuss hyperuricemia Impact on cardiovascular disease in patients with chronic kidney disease.Methods: Select non-dialysis patients with chronic kidney disease who were hospitalized in the Department of Nephrology of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine in June 2019 and December 2019.According to the "Guidelines for Clinical Research on New Drugs of Traditional Chinese Medicine"(2002 edition)Syndrome differentiation of functional failure,conduct syndrome analysis,determine the TCM syndrome type of the patient,and analyze the relationship between the TCM syndrome type and the patient's general information and clinical indicators.In terms of Western medicine,98 patients with non-dialysis chronic kidney disease were grouped,of which 45 patients with hyperuricemia were recorded as HUA group,and 53 patients without hyperuricemia were recorded as control group.The color Doppler ultrasound indexes of the heart were collected and sorted out.The t-test and non-parametric test were used to analyze the two groups of data.Multiple regression analysis was used to analyze the factors affecting the blood uric acid level.Multiple linear stepwise regression analysis was conducted to study the influence of the respective variables on the left ventricular mass score.Results:1.The distribution of TCM syndromes is the most common in 38 cases of liver and kidney yin deficiency(38.8%),followed by 23 cases of qi and yin deficiency(23.5%),21 cases of spleen and kidney yang deficiency(21.4%),and spleen and kidney.There were 16 cases of Qi deficiency syndrome(16.3%),and 39 cases(39.8%)of dampness and turbidity syndrome were the most common evidence,followed by 34 cases of dampness and heat syndrome(34.7%),23 cases of blood stasis syndrome(23.5%),and 2 cases of water and gassyndrome.(2%).2.The mean LDL-C value was highest in the spleen and kidney qi deficiency group,and the Scr was highest in the qi and yin deficiency group.There were no statistical differences in SUA,Hb,Ca,P,ALB,LVDd,PWT,LVMI,and IVST indicators among the groups.3.There was no statistical difference between HUA group and control group in terms of gender,age,height,weight,BMI,blood pressure,smoking,drinking,history of hypertension,history of diabetes,history of cardiovascular disease,P>0.05.4.Compared with Scr,Urea,P,HDL-C,e GFR,Hb,Ca of HUA group and control group,P<0.05,the difference was statistically significant.Compared with CHOL,TG,LDL-C,ALB of HUA group and control group,P>0.05,the difference was not statistically significant.Compared with the control group,the color Doppler ultrasound indexes LVDd,IVST,PWT,LVEF,E/A,LVMI of HUA group and control group were P>0.05,and the difference was not statistically significant.The proportion of left ventricular hypertrophy in the HUA group was37.8%,and that in the control group was 35.8%.Comparing the two groups of patients,P>0.05,the difference was not statistically significant.5.The correlations between serum uric acid levels and Scr,Urea,P,Ca,e GFR,Hb,HDL-C were statistically significant(P <0.05).The levels of blood uric acid were positively related to Scr,Urea,P,and Ca,e GFR,Hb and HDL-C were negatively correlated.Urea is independently related to blood uric acid levels.6.There is a negative correlation between serum uric acid level and LVEF,and the difference is statistically significant(P <0.05).The effect of e GFR on LVMI is statistically different(P <0.05),and the effect of e GFR is negative,that is,the smaller the e GFR,the larger the LVMI.Conclusion:1.Distribution of TCM Syndrome Types The liver-kidney-yin deficiency syndrome is the most common in this deficiency syndrome,the wet-turbidity syndrome is the most common in the evidence-based syndrome,and the LDL-C mean is highest in patients with spleen-kidney deficiency syndrome.The qi and yin deficiency syndrome group had the highest Scr.2.In undialyzed CKD patients with HUA,there is no direct correlation between SUA level and LVMI.3.The SUA level is positively correlated with Scr,Urea,and P.The higher the SUA level,the higher the Scr,Urea,and P;the SUA level is negatively correlated with Ca,e GFR,Hb,and HDL-C.The higher the SUA level,the lower the Ca,e GFR,Hb,and HDL-C.4.The SUA level is negatively correlated with LVEF.The higher the SUA level,the lower the LVEF.e GFR has a negative correlation with LVMI.The smaller the e GFR,the larger the LVMI value.5.In CKD patients,SUA may indirectly affect LVMI through the decrease of e GFR and the disorder of calcium and phosphorus metabolism,which may cause CVD diseases such as vascular calcification.