Resting-state Functional Magnetic Resonance Imaging Study Of Neurological Soft Signs And Cognitive Function In Childhood-onset Schizophrenia

Objective: To investigate the brain activities of age onset by using by Resting State Functional Magnetic Resonance Imaging(RS-f MRI)on cognitive function and neurological soft signs(NSS)in patients with schizophrenia.To analyze the resting state of brain function in Childhood onset and Adulthood-onset schizophrenia.To explore the relationship between the cognitive function and NSS with resting state brain function in childhood and Adulthood onset schizophrenia.Method: 20 patients with childhood-onset(Age onset?14)schizophrenia and 20 patients with Adulthood-onset(Age onset?18)schizophrenia paired with the former according to age,gender and education years were recruited,respectively as Research Group and Control Group.The cognitive function of patients was evaluated by using neuropsychological scale,and NSS was evaluated in CNI.Using f MRI 3.0 system to check the whole brain RS-f MRI of all the subjects.MATLABR2013 b and SPM8 software was used to analyze the imaging date of preprocessing.All study controls were studied using RS-f MRI Data Analysis Toolkit(DPABI4.3)software to obtain the areas of the brain where the ALFF changes were statistically significant.Analyze of the differences in the static magnetic resonance data between the two groups,then analyze the relationship between ALFF and neurocognitive function and soft physical signs of the nervous system.Results: Compared with adulthood-onset patients,the patients with childhood-onset schizophrenia showed more impairments in visual memory(-3.602,t=-4.925),arithmetic(t=-2.510)and general cognitive ability(t=--2.127)as well as significant higher NSS total scores(t=3.373),Motor Coordination Subscale(t=2.526)and Sensory Integration Subscale(t=2.783)on CNI significantly.Compared to the controls,Childhood-onset schizophrenia showed significantly increased ALFF in right frontal lobe and left occipital lobe(corrected by GRF,Voxel P<0.0214,Cluster P<0.1).schizophrenia right frontal lobe and visual memory(r=0.340,r =0.413),DEX(r = 0.416)and GCA negative correlation(r=0.434),the correlation coefficient test was statistically significant(P<0.05);COS the left occipital lobe ALFF values and negatively correlated with the visual delayed memory(r=0.573),the right frontal lobe ALFF value and negatively correlated with logic instant memory(r=0.646),the correlation coefficient test was statistically significant(P<0.01);Two groups of patients the ALFF value of right frontal lobe and the CNI scale score(r=0.488),movement regulation subscales(r=0.359)and sensory integration subscales(r=0.483)were positively correlated,the correlation coefficient test was statistically significant(P<0.05,P<0.01);The ALFF value of the right frontal lobe of the study group was positively correlated with the total score of CNI scale(r =0.494)and the exercise regulation component(r=0.484),and the correlation coefficient test was statistically significant(P<0.05).Conclusion: 1.Compared with adulthood-onset schizophrenia,childhood-onset schizophrenia impairs worse in cognitive function and neurological soft signs.2.There are some abnormal spontaneous neural activity of the brain regions in COS,which includes the left occipital lobe and right frontal lobe areas.3.The ALFF value changes of some brain regions were closely to the cognitive function and NSS in COS,which prompt cognitive dysfunction may be associated with abnormal spontaneous neuronal activity.