The Brain Mechanism Of Wechsler Adult Memory Scale

ObjectiveThe objective of this study is to explore the brain mechanism of the Wechsler Memory Scale in three dimensions: long-term memory,short-term memory and instantaneous memory using a functional magnetic resonance imaging technique combined with brain structural characteristics and brain function characteristics in a normal adult study.At the same time,the medial temporal lobe of the key brain regions of memory was selected as the seed point for dynamic functional connection analysis to explore the dynamic connected brain circuits in the different sub-regions of the medial temporal lobe in the associative memory of the Wechsler memory subscale.Methods(1)We collected demographic data based on self-designed questionnaires.The memory subscale score and the final memory quotient were obtained by using the Wechsler Adult Memory Scale.Then we collected their resting state fMRI data and T1 structure data.(2)Based on the MATLAB R2014 a platform,the DPARSF software was used to preprocess the functional data and calculate the ReHo and ALFF indicators.The structure images were preprocessed by DATERL toolkit in SPM software and Freesurfer software respectively.Then calculated the voxel morphology index(VBM)and cortical morphological index(SBM)indicators.In addition,Dynamic BC software package was used to analyze dynamic functional connectivity.Finally using SPM software and SPSS software for statistical analysis of MRI data and scale data.Results(1)The relationship between the long-term memory inclusion test of theWechsler Adult Memory Scale and brain function and brain structure indicators:1-100 in long-term memory was negatively correlated with ReHo value of right superior temporal gyrus.100-1 was positively correlated with ALFF values in the right inferior frontal gyrus and left anterior cuneiform lobe,ReHo values in bilateral middle frontal gyrus and right dorsolateral superior frontal gyrus,and VBM values and Volume values in the left insula.Accumulation was positively correlated with ALFF values in the right inferior parietal angular gyrus,negatively correlated with ReHo values in the right middle temporal gyrus and the calcarine cortex,and negatively correlated with VBM values in the left superior temporal gyrus.(2)The relationship between the short-term memory inclusion test of the Wechsler Adult Memory Scale and brain function and brain structure indicators:Visual recognition in short-term memory test was negatively correlated with ReHo values in right fusiform gyrus and right inferior temporal gyrus,positively correlated with ReHo values in left medial superior frontal gyrus and left superior temporal gyrus,positively correlated with VBM values in right inferior temporal gyrus and positively correlated with thickness in right lateral occipital lobe.Picture recall was negatively correlated with the value of VBM in left superior temporal gyrus and positively correlated with the value of VBM in left calcarine cortex and left middle occipital gyrus.Visual regeneration was positively correlated with ALFF values of left parietal gyrus and left paracentral lobule,and ReHo values of right posterior central gyrus,negatively correlated with VBM values of bilateral temporal poles: middle temporal gyrus.Associative memory was positively correlated with ReHo value in the right superior frontal gyrus and VBM value in the left middle frontal gyrus.Tactile memory was negatively correlated with ALFF and ReHo values in the left inferior frontal gyrus and positively correlated with VBM values in the left cuneiform lobe.Comprehensive memory was positively correlated with ALFF value of right middle frontal gyrus,negatively correlated with ReHo value of left middle temporal gyrus and right rectus gyrus,positively correlated with ReHo value of left inferior parietal lobule,negatively correlated with thickness of left posterior cingulate gyrus and right fusiform gyrus.(3)The relationship between the instantaneous memory inclusion test of the Wechsler Adult Memory Scale and brain function and brain structure indicators: The digital memory capacity test included in the instantaneous memory test was positively correlated with the ALFF values of the right superior frontal gyrus,the left rolandic operculum,the left medial superior frontal gyrus,the left superior temporal gyrus and the left posterior central gyrus,negatively correlated with the ALFF values of the left middle occipital gyrus,negatively correlated with the ReHo values of the left lingual gyrus,positively correlated with the ReHo values of the right superior frontal gyrus,the left rolandic operculum,the right anterior central gyrus and the right supraMarginal,positively correlated with the VBM value of left superior temporal gyrus and right calcarine cortex,and negatively correlated with curv of right posterior cingulate gyrus.(4)The relationship between the Memory Quotient of the Wechsler Adult Memory Scale and brain function and brain structure indicators: MQ was positively correlated with ALFF values of left anterior cingulate gyrus,right posterior central gyrus and left supplementary motor area,negatively correlated with ReHo values of left inferior temporal gyrus and right lingual gyrus,positively correlated with ReHo values of left anterior cingulate gyrus,paracingulate gyrus and right posterior central gyrus,negatively correlated with VBM values of left temporal pole: middle temporal gyrus,and positively correlated with VBM values of left calcarine cortex.(5)Dynamic Functional Connection Analysis Based on Seed Points between the associative memory test in the Wechsler Adult Memory Scale and the medial temporal subregions: We found that the distribution of the left and right brains in different subregions of the MTL differed in the degree of involvement in associative memory and some subregions involved in associative memory retrieval have different functions,mainly focusing on visual vocabulary recognition,speech information processing,semantic retrieval,information encoding and contextualization.ConclusionsIt was found that each subscale was significantly correlated with ReHo,ALFF,VBM,SBM and other indicators in some regions of the whole brain.This shows thatthe Wechsler Memory Scale can reflect individual memory ability from the perspective of brain structure and function.Secondly,we identified the cortical regions of dynamic functional connectivity in different MTL subregions and described their functional roles for the retrieval of associative memory.This study provides theoretical support for the neurobiological basis of the Wechsler Adult Memory Scale,which can be used as a reference for the evaluation of clinically relevant diseases,allowing us to have a deeper understanding and understanding of the memory defect mechanisms generated by the disease.