| Bet placing is a very common phenomenon of risk decision making in life.In this study,we sorts out the relevant theoretical and empirical researches that influence risk decision-making.It is found that most of the research in the past two decades has focused on the theoretical development of risk decision-making and the influencing factors.The study of influencing factors focused on common demographic factors,without considering the role of other influencing factors in risk decision making,such as genetics,a biogenetic factor.Some decision-making studies in genetic in recent years have shown that some genes related to dopamine or serotonin can influence our risky decisions,because dopamine is mainly involved in reward processing,while serotonin related to emotions.It is well known that the cannabinoid system is closely related to addictive behavior and addictive behavior is often accompanied by risk management and reward processes.However,little is known about whether the cannabinoid system-related genes influence the bet placing in risk decision-making.To investigate this question,we selected rs1049353,a single nucleotide polymorphism of the cannabinoid 1 receptor gene(CNR1),to study the effect of CNR1 gene on betting behavior.Because a large number of studies have shown that this site was related to addictive behavior and reward processing.In this study,we conducted an experimental study of a total of 430 Chinese undergraduate students in two studies.We used an adapted Cambridge gambling task to test the effect of the rs1049353 polymorphism on people’s bet placing.This study uses experimental research to try to solve the following problems.First,to test the applicability study of the revised version of the Cambridge gambling task in Chinese sample.Second,the effect of rs1049353 of the cannabinoid 1 receptor gene CNR1 on the betting behavior of the subjects.Thirdly,exploring the underlying neural mechanism of the cannabinoid 1 receptor gene affecting the betting behavior.The applicability study of the Cambridge gambling task in the study one in the Chinese sample was tested.The results showed that:(1)the bet placing of the Chinese participants in the revised Cambridge gambling task was significantly affected by the proportion of red and blue boxes.The greater the difference in the number of red and blue boxes,the greater the amount of bet placed by the participants.(2)The response time for bet was significantly affected by the proportion of red and blue boxes.Thereaction rate at a small scale level(4:5 and 3:6)is much higher than at the large scale level(7:2 and 8:1).In the second study,the effect of different genotypes of rs1049353 of the cannabinoid type 1 receptor gene CNR1 were studied.The results showed that:(1)The amount of bet by the subjects carried the C/C genotype was significantly higher than that of the subjects carried the C/T genotype.(2)The response time for bet of the subjects carried the C/C genotype was much higher than that of the C/T genotype.(3)The mean value of the R index of the subjects carried the C/C genotype was much higher than the mean of the subjects carried the C/T genotype.We further studied the gene expression map in the Allen Human Brain Atlas and found that CNR1 gene was overexpressed in the striatum,amygdala and hippocampus.It is well known that these brain structures participate in reward and risk processing.Our results suggest that,to a certain extent,in the healthy subjects,high level social and risk decision-making just like bet behavior may also be affected by single genetic locus variation.In addition,CNR1 gene may play a role by regulating brain regions involved in rewards and risk management. |
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