Study On The Regulation And Application Of Near-infrared Absorption Performance Of Copper Sulfide

Near-infrared laser has attracted much attention due to its good biological tissue penetrability and almost no tissue damage,which is widely used in the biomedical field.In order to give full play to the role of near-infrared lasers in living organisms,it is necessary to develop light-heat-conversion nanomaterials or devices to match the wavelength of the laser.In recent years,copper sulfide nanomaterials have been widely used for the diagnosis and treatment of tumors because of their advantages of low cost,low toxicity,and strong near-infrared absorption.However,there are still some problems in the application of it to the living body.For example,when it is administered by intravenous injection,it is easily trapped by normal tissues and organs,which greatly interferes with the diagnosis and treatment of the tumor.In addition,most of the applications of copper sulfide are focus on the biomedical field and it is urgent to expand its application.Based on this,three parts of work are carried out as shown follows:Part 1:Considering that high-performance nanomaterials with bio-response characteristics can effectively solve the interference problem of contrast materials in normal tissue,a temperature-responsive copper sulfide photoacoustic contrast agent was developed for cancer diagnosis.The temperature can control the transformation of the crystalline state of copper sulfide,resulting in strong near-infrared absorption which can be used for photoacoustic imaging.Firstly,the ultra-small copper sulfide amorphous nanoparticles with a small size(-5 nm)and weak near-infrared absorption was obtained by mixing the bovine serum albumin(surfactant),copper chloride and thioacetamide at 25 ? for 2 hours.Under the simulating biological body temperature,the amorphous copper sulfide can transfer to platy crystalline CuS nanomaterial with a big size(?21 nm)and strong near-infrared absorption.Then,tumor beard mouse model was used to demonstrate that the body temperature can trigger this smart copper sulfide to become photoacoustic contrast agent.The results suggest that this smart copper sulfide photoacoustic contrast agent can significantly improve contrast of tumor tissues and normal tissues.Part 2:In order to overcome the application limitation of low photothermal conversion efficiency of CuS nanomaterials,a flower-like self-doped CuS superstructure with good near-infrared thermal conversion capability was designed and synthesized based on that superstructure and self-doping effects can effectively improve the photothermal conversion efficiency.The CuS with uniform structure,good dispersion and strong near-infrared absorption was prepared by solvothermal method using polyvinylpyrrolidone as surfactant and weak reducing agent and N-methyl pyrrolidone as solvent.At the same time,the regularities about how the weak reducing agent influences the structure and near infrared absorption property of CuS were summarized.Part 3:In order to expand the application of CuS superstructure photothermal conversion materials,a flexible CuS film with good high temperature resistance was prepared by coating method using the dispersion of CuS materials and polyimide polymer in N-methyl pyrrolidone.The photo-thermal performance test results show that the CuS film irradiated by 808 nm laser can reach the maximum temperature of 140 ? instantaneously,which proves that the photothermal conversion film material has the advantages of rapid temperature increase and high conversion efficiency.Subsequently,we initially explored the application of this membrane material in three fields of laser-driven switches,generators,and seawater purification,demonstrating that the membrane material has a good application prospect.