Continuous Research On Instantaneous Nano-preparation Technology

Nanodispersions in water,such as water-borne nanosuspensions and nanoemulsions,widely exist in nature,and are closely related to life processes,environments,scientific researches,daily life,and manufacturing.It has been a challenging topic to massively,continuously,controllably,economically produce narrowly size-distributed nanodispersions of solid or liquid hydrophobic compounds.Flash nanoformation(FNF)is a facile technology capable to produce water-borne nanodispersions in a fast,massive and controllable way,and shows bright prospects in many industries.However,the FNF is still in the stage of lab developments and the continuous production of nanodispersions has not been realized yet.This thesis employs the theoretical analysis,the numerical simulation via computational fluid dynamic(CFD)and the experimental testing,and endeavors to realize the continuous process of the FNP in terms of either the preparation method or the operational process.The detailed works are as follows.1)successfully develops a theoretical model on the energy dissipation in the chamber of the confined impinging jet(CIJ)mixer,investigates the quantitative relations between the conversion to interfacial energy of nanoparticles,structural parameters of the chamber and the mixing parameters,and achieves the key factors affecting the energy conversion and particle size;2)achieves the values of the energy conversion to interfacial energy of the nanoparticles based on the nonsourced Bounoulli equation,and theoretically verifies the high energy efficiency and the negligible temperature change in the chamber;3)builds a fabrication platform for the CIJ mixer;4)employs the CFD numerical simulation to facilitate the determination of structural parameters and mixing parameters;5)explicates the reason on the convergent and minimum particle size once the total Reynolds number(ReTI)is greater than a critical value of ReTI(ReTIc);6)modifies the two-inlet confined impinging jet with dilution(CIJ-D)mixer by adding more inlets as well as a circulation inlet,and design and fabricate a three-inlet confined impinging jet with loop(CIJ-L)mixer,a four-inlet confined multiple impinging jet(CMIJ-L)mixer,and a five-inlet confined multiple impinging jet with loop(CMIJ-L)mixer;7)successfully design and build automated apparatus with above mixers;8)produces the coenzyme Q10 nanosuspensions by using the automated mixing apparatus,and validates the design and fabrication of the mixer,design of the preparation process,design and building of the automated apparatus and its operational procedures.9)produces the chitosan stabilized coenzyme Q10 nanosuspensions and Tween 80 stabilized orange oil nanoemulsions via the FNF with loop and automated mixing,and compares with the FNF without loop by using the automated apparatus,the FNF operated in manual,and the method of drop and stir to demonstrate advantages of the FNF with loop and automated mixing.With above works done,this thesis realizes a process continuity of the FNF in terms of both the preparation method and the operational process.Beneficial to the FNF applications in various industries,this work would provide for the FNP the theoretical basis on the flash mixing,the mixers,automated apparatus and operational procedures,as well as give guidance on determining mixing parameters.