Synthesis Of Fluorescent Transition Metal Complexes With Potential HIV Reverse Transcriptase Inhibitory Activity

Exploration of the structure and modulation of the function of RNA have turned to be an important topic in chemistry,biology and life science.Reverse transcription of virus RNA is the toxicology basis of many dread diseases,Such as cancer,AIDS and leukaemia.Rational design of drugs based on inhibition of the activity of reverse transcriptase is of essential interest in current development of antitumor and anti-HIV drugs.Here we design three types mental complexes,the groups specifically recognized by RNA were introduced into porphyrins,polypyridyls,and phthalocyanines.The paper is divided into four chapters.the first chapte reviews the research progress of anti-HIV drugs and the research progress of porphyrins,phthalocyanines,polypyridylium compounds.In the second chapter we introduce the specific synthetic route of the three types of transition metal complexes.In the third chapter,We use UVVis-spectral titration investigate the 11 mental complexes interation with four kinds of nucleotides.Results suggest that the metalloporphyrin complex incorporating the aminothiazole group and tert-butyl group have strong binding ability to nucleotieds.In the polypyridinium metal complex,Ru4 shows good selectivity to Poly(A).The last chapter describes the specific experiment procedure and spectrum data of the resultant compound.