Study On A New Method For Substitution Of Imidazo[1,2-a]pyridine C-3 Radicals

Imidazo[1,2-a]pyridine has special drugs and biological activity,which is widely found in drug molecule fragments.So far,there has been a number of drugs with this structure in the market,such as Alpidem,Zolpidem,Minodronic Acid,Nicopidem,Saripidem,Zolimidine and so on.In nearly a decade,significant progress has made on the study of the structure.Using a variety of ways to synthesis compounds which had special biological activities has become one of the most important topics in organic chemistry.At the same time,visible light catalysis induced free radical in organic chemical reactions has caused the wide attention of chemical workers immediately because the visible light is eco-friendly,low energy consumption,convenient,and has many other advantages.Because of the unique bioactivity of Imidazo[1,2-a]pyridine compounds and derivatives,and the continuous research of visible light catalysis in organic chemistry.In the work of this thesis,we modified the imidazo[1,2-a]pyridine C-3 position through the method of producing free radicals by photocatalysis,which mainly including the following two parts:1.Visible-Light-Induced Regioselective cyanomethylation of imidazopyridines was achieved using of cheap and easily available bromoacetonitrile as cyanomethyl source and the drugs Zolpidem and Alpidem were further transformed.2.Using heterocyclic compounds with bromine as heterocyclic source of free radicals by visible light catalysis implements the imidazole[1,2-a]pyridine C-3 heterocyclic coupling reaction under mild conditions.The reaction has been proved to be carried out through the means of free radicals,and synthesis of heterocyclic compounds which may be bioactive.