Study On The Remote Activation Of Unsaturated Carbonyl Compounds Catalyzed By Nitrogen Heterocyclic Carbene And Related Reaction Modes

Aromatic cytoskeleton compounds are widely used in functional molecules.As an important member of aromatic rings,multi substituted phenyl rings are widely reported in natural products,drug chemistry and small pesticides.Nitrogen heterocyclic Carbene(N-heterocyclic carbene,NHC),as a good nucleophilic catalyst,has a good catalytic activity for carbonyl compounds,and ester as a class of stable carbonyl compounds has been the difficulty and hot spot of NHC catalysis.In recent years,chemists have made remarkable achievements in the study of the reaction of active esters catalyzed by NHC,especially the high chemical selectivity for the remote activation of the esters.This article is narrating from two aspects: the first part reviews the development of NHC catalyst,and the important catalytic activation modes,especially the research progress of high stereoselectivity and chemical selective reaction mode realized under remote activation.A series of literature studies on the synthesis of multi substituted aromatic rings were carried out.In the second part,NHC is used to construct a multi substituted benzene ring compound under the conditions of exogenous oxidants.The optimal reaction conditions of the model reaction were determined through screening of catalysts,oxidants,additives and solvents.On this basis,the universality of the model reaction was explored,and some products with good yield were obtained.