RAFT Polymerization Can Control The Preparation Of Polymer Nanocomposites With Photothermal Effect And Their Application In Drug Release

In this article,the recent advances in constructing PTT therapeutic and multi-model combination therapeutic via integrating nanomaterials and functional polymers were summarized.Subsequently,several different functional polymers were synthesized via RAFT polymerization.First,we synthesized a targeted photothermal controllable nanocarrierconsistingofMoS₂nanosheetsmodifiedwithcopolymer P（OEGA）-b-P（VBA-co-KH570）and loaded the drug doxorubicin.Second,a self-guided photothermal and drug nanocarrier based on MoS₂ nanodots modified with copolymer P（OEGA-co-VBA）and targeting ligands of transferrin was designed and synthesized.The details are as follows:Combination of chemotherapy with photothermal therapy into one system is an effective strategy to further improve the therapy efficiency.In our review,we focus on the recent advances in constructing PTT therapeutic and multi-model combination therapeutic via integrating nanomaterials and functional polymers.The well-defined block copolymer P（OEG-A）-b-P（VBA-co-KH570）was prepared by RAFT polymerization and then grafted onto the MoS₂ nanosheets based on the Si-O-Mo linkages.The block copolymer is utilized not only to enhance the solubility of MoS₂nanosheets but also efficiently load the drug doxorubicin through the formation of a pH-responsive Schiff base bond.Subsequently,thiol-functionalized transferrin was anchored onto the surface of MoS₂ nanosheets by the formation of disulfide bonds to enhance the cellular uptake.The photothermal effect and drug release ability were further explored in vitro and in vivo.A self-guided photothermal nanocarrier based on MoS₂ nanodots modified with copolymer P（OEGA-co-VBA）and targeting ligands of transferrin was synthesized.The copolymer P（OEGA-co-VBA）was synthesized via RAFT polymerization and not only utilized to improve the biocompatibility of MoS₂ NDs,but also efficiently load the drug doxorubicin via acid-cleavable Schiff base bonds.Besides,thiol functionalized transferrin was anchored onto the surface of MoS₂ NDs via the formation of disulfide bonds,which could further enhance the cellular engulfed of MoS₂ NDs nanocarrier.The modified MoS₂nanoagents show better therapeutic effect,which suggest the designed MoS₂ nanocarrier is promising for applications in multi-modal biomedical field.