Study On The Reaction Of Electrophilic Trifluoromethylthio Reagents With ?-diazocarbonyl Compounds

Compounds containing trifluoromethythio group play an important role in materials,pharmaceuticals and agrochemicals.Related research has received widespread attention from chemists in recent years.This paper explored the reaction between ?-diazo carbonyl compounds and electrophilic trifluoromethylthiol reagents under mild conditions,characterizing the properties of the related products and suggesting possible mechanisms.A new use of N-trifluoromethylthiosaccharin has been found.This experiment explored the use of ?-diazo carbonyl compounds,which play an important role in organic synthesis,as a substrate,and screened several kinds of electrophilic trifluoromethyl sulfide reagents that were widely used today,and found that N-A relatively good yield of trifluoromethylthiosuccinyl(ie,Ntrifluoromethylthio-benzoylsulfonimide)has been achieved,and we have also followed the factors that may affect the reaction(eg,temperature,solvent,etc.)In a series of controlled experiments,the optimal reaction conditions were determined.It was found that this reaction uses methylene chloride as a solvent at room temperature and the reaction has the best selectivity.The experiment fully demonstrates the feasibility and high efficiency of the studied method.Compared with traditional methods,this method does not involve the use of metal catalysts and the reaction is more green and environmentally friendly.Finally,the trifluoromethylthiol reagent used in this study is stable and easy to prepare.This method has great potential application value in the fields of pharmaceuticals,pesticides and organic synthesis.