Design And Synthesis Of Metal Complexes

Cancer is one of the most serious malignant diseases that threaten human life and health.As the incidence of cancer continues to rise,the search for cancer treatment has become an urgent need.According to statistics,the incidence of cancer has exceeded the cardiovascular and cerebrovascular diseases as the first cause of death.In 2015,about 4.3 million people were diagnosed with cancer in China,and as many as 2.8 million people died of cancer.Cancer has become the leading cause of death in China.At present,cancer treatment mainly through radiation therapy,chemical drug therapy,and surgical treatment,among which chemotherapy is the main treatment.Among chemotherapeutic drugs,cisplatin,carboplatin and oxaliplatin are the three most representative metal anticancer drugs.Among them,cisplatin is the representative or involved in chemotherapy,accounting for 70%-80% of all chemotherapy.A representative anticancer drug is also the most effective anticancer drug,especially for the treatment of cancer of the reproductive system and cervical cancer.The discovery and development of metal platinum drugs has opened a new field of metal anticancer drugs,opening the way for the development of metal anticancer drugs.With the clinical use of metal platinum drugs,side effects have gradually emerged,such as cancer drug resistance,drug efficacy,and side effects such as nephrotoxicity,ototoxicity,nerve damage,etc.The emergence of side effects has prompted people to look for drugs that are different from the anticancer mechanism of platinum drugs.Since 1967,the emergence of platinum-based metal drugs has fully demonstrated the great medicinal value and anti-cancer potential of metal complexes.However,its problems have prompted people to look for more efficient,selective cancer cells,clear targets,and metal anticancer drugs different from platinum anticancer drugs.At home and abroad,through research on anticancer drugs such as metal bismuth,it has been found to have excellent anticancer activity.It is worth noting that three metal strontium anticancer drugs have been used in clinical research and have achieved good results.Metal anticancer complexes such as strontium can be developed into anticancer drugs with great advantages.For example,the anticancer activity of metal complexes can be easily and easily improved by adjusting the structure-activity relationship,such as changing ligands or metals.2.The metal anticancer complex designed and developed has a novel anticancer mechanism different from clinical platinum anticancer drugs.3,can overcome the single deficiency of existing anticancer drugs,selectively kill cancer cells through multiple channels.Design and synthesis of complexes with specific organelle targeting,creatively combine the "cell imaging","high anticancer activity","specific selectivity to cancer cells" and "biocatalytic activity" of metal complexes.4,new research methods and means to carry out in-depth systematic metal complex lysosomal targeting research,dynamic tracking imaging research and complex anticancer mechanism research,for the development of potential lysosomal targeted diagnostic reagents and fluorescent probes to lay the theoretical and experimental foundation for the development of new metal anticancer drugs.In this experiment,a series of metal anticancer complexes were designed and synthesized,and the anticancer mechanism of metal drugs was deeply studied systematically,which laid a foundation for the development of metal drugs.We studied the hydrolysis chemistry of complexes,nucleobase binding,interactions with ctDNA and BSA,and the toxicity of these complexes to cancer cells of HeLa and A549 cancer cells.At the same time,the anti-cancer mechanism of these complexes was further analyzed by cell cycle,ROS,apoptosis and catalytic hydrogen transfer.At the same time,these complexes not only exhibit potent anti-proliferative activity,but also exhibit specific target lysosomes and damage to lysosomes,resulting in cathepsin from lysozyme after increased lysosomal membrane permeabilization(LMP).The body releases into the cytosol and triggers apoptosis.In addition to these studies,nucleobase binding,reaction with GSH,cell cycle,mitochondrial membrane potential(MMP)changes,and catalytic conversion of NADH were also investigated.We have demonstrated that such complexes are attractive new bioimaging and anticancer agents.Studies have shown that the synthesized metal anticancer drugs have high anticancer activity,cell targeting,low toxicity,selective killing of cancer cells,etc.,and will certainly attract widespread attention in the field of metal anticancer drugs.