Multifarene [3, 3] Modified Graphene To Construct A Supramolecular Sensor And Its Molecular Recognition Performance

Supramolecular chemistry has promoted the development of many other disciplines,including traditional chemistry?e.g.,organic chemistry,inorganic chemistry,physical chemistry and analytical chemistry?and new-rising subjects?e.g.,information science,material science,energy science,environmental science,and life science?,to exhibit strong vitality.In recent years,electrochemical technology has been developed and keeps improving.So far,the technology can be employed in more science research fields,and its application has been further expanded.In the aspect of electrochemical sensors,scientists constructed supramolecular electrochemical sensors with introduction of macrocycles onto the electrode surface to provide excellent supramolecular recognition performance,with the specifically identify and affinity analytes by macrocyclic hosts.In this paper,a new class of supramolecular macrocycle,Multifarene and its derivative,were used as the decoration material,and combined with the superior electrochemical properties of graphene,to design and construct the supramolecular electrochemical sensors successfully.1.The host-guest recognition of Multifarene[3,3]to catechol and dopamine was identified.And an electrochemical sensor was presented with a composite of the macrocyclic host,multifarene[3,3],to offer the supramolecular recognition,with graphene to enhance the electrochemical response.The morphology and structure of the composites were characterized by atomic force microscopy,transmission electron microscopy and Raman spectroscopy,and the electrochemical behaviors of catechol and dopamine on the proposed electrochemical sensor were measured by cyclic voltammetry and differential pulse voltammetry.At a working potential of 160 m V?vs.Ag/Ag Cl?,the electrochemical sensor displayed a differential pulse voltammetric response in the linear concentration range of 10-100 n M within a detection limit of0.51 n M?at S/N=3?of catechol.At a working potential of 180 m V?vs.Ag/Ag Cl?,it displayed a differential pulse voltammetric response in the linear concentration range of 10-100 n M within a detection limit of 0.62 n M?at S/N=3?of dopamine.In addition,the electrochemical sensor showed good reproducibility,stability and anti-interference.It was also exhibited satisfactory results to the determination of dopamine injections,indicating a certain practical application propect.2.The macrocycle,Chiral hetero-multifarene[3,2,1]?CHMF?,was synthesized,and the nanohybrids of CHMF functionalized graphene was prepared.A chiral supramolecular electrochemical sensor to recognize tyrosine?Tyr?enantiomers was constructed with the nanohybrids.The structure and morphology of the hybrids were characterized by FT-IR spectrophotometer,thermogravimetric analysis,atomic force microscopy and transmission electron microscopy.The electrochemical behavior of L-Tyr or D-Tyr on the constructed chiral sensor was investigated by differential pulse voltammetry,the ratio of the peak current of L-Tyr to D-Tyr equal 1.58(I_L-Tyr:I_D-Tyr=1.58)and the peak potential difference?Ep=70 m V,the results suggested that the chiral sensor had the excellent enantiorecognition capability to distinguish Tyr isomers.The sensor can be employed to detection L-Tyr or D-Tyr,L-Tyr was detected at the linear concentration range of 0.1-10?M with a detection limit of 78 n M?at S/N=3?and D-Tyr was detected at the linear concentration range of 0.1-10?M with a detection limit of 83 n M?at S/N=3?.In addition,the proposed chiral sensor was subjected to measure the responding current to different enantiomeric percentage of L-Tyr and D-Tyr within a total concentration,the results suggested the constructed electrode of r GO-CHMF/GCE offered a practical approach for quantitative determination of the ratio of one Tyr enantiomer in a racemic solution.And the further investigations demonstrated that the electrochemical chiral sensor had good reproducibility,stability and anti-interference.