| Purpose:PETCT has been widely recognized for diagnosing and staging lung cancer,but the prognostic value of maximum standardised uptake value(SUVmax)in non-small cell lung cancer(NSCLC)is still controversial.This paper aimed to determine whether the amount of fluorine-18 fluorodexyglucose(FDG)has prognostic significance in patients with advance-stage non-small-cell lung cancer(NSCLC).Patients and Methods:We collect a total of 157 advanced(stage IIIB-IV)NSCLC patients confirmed by histology or cytology from June 2012 to June 2016.Extensive clinical data,including the maximum standardized uptake value(SUVmax),tumor histologic cell type,pathologic stage at presentation,and treatment,were recorded.SPSS 19.0 was used for statistical analysis.We performed univariate survival analysis with Kaplan-Meier method and the comparision between groups was tested by the log-rank test.Multivariate analysis was performed with the Cox proportional hazards model.Patient survival time was defined as the time between final diagnosis and the last follow-up or death time.Results:One hundred forty-four of the 157 patients died and 13 patients were reported alive at 19 months(range,1 to 68months)after the diagnosis of NSCLC.Using the SUVmax of 7,the patient population was subdivided.The median survival of the 75 patients with the primary tumor having an SUVmax less than 7 was 23 months(95%CI,18 to 28months),whereas the median survival of the 82 patients with the primary tumor having an SUVmax>7 was 16 months(95%CI,11 to 20months).Univariate and multivariate analysis provide evidencethat survival for patient subgroups defined by the median SUVmax were significantly different(univariate P=0.002;multivariate P=0.032;HR=0.644;95%CI:0.431?0.963).Conclusion:high SUVmax(>7)of the primary tumor on 18F-FDG PET/CT scan predict shorter OS in advanced stage of NSCLC.FDG uptake of the primary lesions in patients with a new diagnosis of advanced-stage NSCLC have a significant relationship with survival. |
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