Analysis Of Risk Factors Of Neonatal Hypoxic-ischemic Encephalopathy And The Application Of Serum S100β In Brain Injury

Part 1Analysis of Risk Factors of Neonatal Hypoxic-ischemic EncephalopathyObjective: This study retrospectively analyzed the risk factors of neonatal hypoxic-ischemic encephalopathy to provides clinical basis for early diagnosis and prevention of neonatal hypoxic-ischemic encephalopathy.Methods: From May 2013 to May 2018,statistics were collected on newborn babies delivered in the Obstetrics Department of Qingdao Municipal Hospital at the same time admitted to Neonatal Intensive Care Unit.There are 52 neonates with hypoxic-ischemic encephalopathy diagnosed as HIE that were selected as HIE group.At the same time,78 normal newborns(except other brain diseases)were randomly selected non-neonatal hypoxic-ischemic encephalopathy as a control group which there was no statistical difference in gestational age,weight and gender of obstetric delivery in this hospital at the same time admitted to Neonatal Intensive Care Unit through SPSS 19.0 statistical software(P>0.05)during the same period.Two groups of related information were collected,including the general situation of children(gender,gestational age,birth weight,Apgar score),amniotic fluid pollution,gestational diabetes mellitus,gestational hypertension,preeclampsia,intrauterine distress,premature rupture of membranes.To analyze whether it affects the incidence of neonatal hypoxic-ischemic encephalopathy and whether it is a risk factor for neonatal hypoxic-ischemic encephalopathy.Results: According to SPSS 19.0 statistical software analysis,the mothers with gestational diabetes mellitus rate,gestational hypertension and preeclampsia rate,amniotic fluid pollution rate,intrauterine distress rate,premature rupture of membranes rate that the abnormal rate of Apgar score(1 min after birth and 5 min after birth)was higher compared with the control group,in HIE group.There were differences between the groups,which were statistically significant(P<0.05).Multivariate logistic regression analysis showed that gestational diabetes mellitus,pregnancy-induced hypertension or preeclampsia,amniotic fluid pollution,intrauterine distress and premature rupture of membranes were risk factors for neonatal hypoxic-ischemic encephalopathy(P<0.05).And Apgar score(1min after birth)was the protective factor for neonatal hypoxic-ischemic encephalopathy.Conclusion: Mothers with gestational diabetes mellitus,pregnancy-induced hypertension,preeclampsia,amniotic fluid contamination,intrauterine distress and premature rupture of membranes were risk factors for neonatal hypoxic-ischemic encephalopathy.And Apgar score(1min postnatal)was a protective factor for neonatal hypoxic ischemic encephalopathy.That is the higher the score,the lower the incidence of hypoxic-ischemic encephalopathy.Part 2Application of Serum S100β Protein in Neonatal Hypoxic-ischemic Brain DamageObjective: To study the application value of serum S100β protein in early evaluation of neonatal hypoxic-ischemic brain damage.Methods: Thirty neonates with hypoxic-ischemic brain injury who gave birth in the Obstetrics Department of Qingdao Municipal Hospital at the same time admitted to Neonatal Intensive Care Unit from January 2017 to December 2018 were statistically collected as the observation group.At the same time,30 cases of general neonates(Note:No history of asphyxia and hypoxia,no intrauterine infection and no nervous system diseases)in the obstetrics department of this hospital in the same period were randomly selected as the control group.2 ml of femoral venous blood was collected within 72 hours after birth.Immunochromatography was used to detect the serum S100β protein.The values of serum S100β protein were compared between groups.Analyze whether there is a difference in serum S100β protein values between the observation group and the control group.Results: According to SPSS 19.0 statistical software analysis,serum S100β protein levels in the observation group were significantly higher than those in the control group within 72 hours after birth,and the difference was statistically significant(P<0.05).Conclusion: The level of serum S100β protein in the observation group was significantly higher than that in the control group.It is clear that S100β protein has early evaluation value for neonatal hypoxic ischemic brain damage.