A Systematic Review Of Fire Needling In The Treatment Of Vitiligo

Backgrouand:Vitiligo is a common clinical dermatosis with loss of pigment,which is easy to diagnose and difficult to treat.At present,the etiology of vitiligo is still unclear.As a component of traditional Chinese medicine,fire acupuncture is often used in the treatment of many kinds of skin diseases,and has been gradually paid attention to in the treatment of vitiligo.Purpose:To evaluate the efficacy and safety of fire acupuncture in the treatment of vitiligo.Material and method:As of December 2017,CNKI,CQVIP,Wanfang Database,To collect the literature on the treatment of vitiligo by fire acupuncture(RCT).According to the inclusion and exclusion criteria,to screen out the literature that needs to be evaluated.To evaluate the bias risk of the final literature according to the manual provided by Cochrane collaboration,and to analyze the outcome index by meta.Results:A total of 14 randomized controlled trials were included in this study.According to the clinical homogeneity,they were divided into three groups for meta analysis.The results showed that the effective rate of fire needle combined with tacrolimus alone was higher than that of tacrolimus alone [P=0.04<0.05,RR=1.18,95%CI(1.01,1.39)],the effective rate of fire needle combined with UVB irradiation was higher than that of UVB alone[P<0.00001,RR=1.45,95%CI(1.25,1.68)];the effective rate of fire needle combined with traditional Chinese medicine was higher than that of traditional Chinese medicine alone.The effective rate of oral administration of traditional Chinese medicine[P=0.02<0.05,RR=1.21,95%CI(1.03,1.42)] Conclusion:The results of meta analysis indicated that the combination of fire acupuncture and tacrolimus was safe and effective,which could improve the clinical effective rate,but there were few studies on the treatment of vitiligo by single fire acupuncture.Can not effectively judge the efficacy of single application of fire for vitiligo,by the number of samples included,the quality of literature,but also need more high-quality,large sample of clinical data to support.