A Clinical Study Of Corneal Oxygen Therapy Combined With Ultrasonic Nebulization Of Traditional Chinese Medicine In The Treatment Of Moderate To Severe Dry Eye

Purpose: The Keratograph 5M was used to observe the clinical efficacy of corneal oxygen therapy combined with Chinese medicine fumigation combined in the treatment of moderate to severe dry eyes and to explore its mechanism of action.Method: A total of 100 patients(200 eyes)with moderate to severe dry eye from the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected and randomly divided into a treatment group of 50 patients(100 eyes)and a control group of 50 patients(100 eyes).In the treatment group,50 patients(100 eyes)were treated with corneal oxygen therapy combined with traditional Chinese medicine fumigation and washing.Local corneal oxygen therapy: Connect the eye mask with an oxygen generator,and instruct patients to fasten the eye mask to the eyes and open their eyes,and adjust the oxygen flow rate to 3-4L / min,oxygen concentration is 100%,10 min / times,1 time / day;Chinese medicine fumigation and washing: take 20 m L Shengmai injection(Yibin Wuliangye Group Yibin Pharmaceutical Co.,Ltd.,Sichuan Province,Z51022476,main ingredients: Red ginseng,Ophiopogon japonicum and Schisandra chinensis)were added to the fumigator,and the patients were instructed to fasten their goggles to their eyes and open their eyes for 10 minutes,once a day;50 patients in the control group(100 eyes)took 0.3% sodium hyaluronate Eye drops treatment,1 drop / time,4 times / day.The course of treatment was 20 days.Keratograph 5M ocular surface comprehensive analyzer was used to collect evaluation indexes such as the first tear film rupture time(NIBUTf),the average tear film rupture time(NIBUTav),and the tear river height(LTMH)before and after treatment.Scores of dry eye symptoms before and after treatment were recorded.Result: 1.There was no statistically significant difference in age and gender between the treatment group and the control group(P>0.05).The average course of the treatment group was(1.59±0.90)years,and the average course of the control group was(1.85±0.82)years.There was no statistically significant difference in the course of disease between the two groups(P>0.05).2.The symptom score of the treatment group was 59.33±6.76(points)before treatment and 35.96±7.66(points)after treatment.Before and after treatment,t=-24.822,P<0.001,with statistical significance(P<0.05);The symptom score of the control group was 56.92±7.32(points)before treatment and 39.75±7.74(points)after treatment.Before and after treatment,t=-15.984,P<0.001.Comparison of symptom score between the two groups after treatment,t=-2.463,P=0.016,statistically significant(P<0.05).3.NIBUTf in the treatment group was 4.87±2.73(s)before treatment and 8.82±4.78(s)after treatment.Before and after treatment,t=-10.066,P<0.001,with statistical significance(P<0.05);the control group NIBUTf It was 4.55±1.81(s)before treatment and 5.06±2.09(s)after treatment.Before and after treatment,t=-6.855,P<0.001,with statistical significance(P<0.05).The NIBUTf comparison between the two groups after treatment was t=7.219,P<0.001,which was statistically significant(P<0.05).4.Treatment group NIBUTav was 8.51±4.28(s)before treatment,12.91±5.15(s)after treatment,before and after treatment,t=-11.704,P<0.001,with statistical significance(P<0.05);control group NIBUTav It was 7.15±3.27(s)before treatment and 7.91±3.69(s)after treatment.Before and after treatment,t=-6.215,P<0.001,which was statistically significant(P<0.05).After treatment between the two groups,the NIBUTav group was compared,t=-7.909,P<0.001,which was statistically significant(P <0.05).5.The treatment group LTMH was 0.14±0.06(mm)before treatment and 0.24±0.06(mm)after treatment.Before and after treatment,t=-21.769,P<0.001,with statistical significance(P<0.05);the control group LTMH It was 0.21±0.05(mm)before treatment and 0.22±0.06(mm)after treatment.Before and after treatment,t=-5.873,P<0.001,with statistical significance(P<0.05).After treatment between the two groups,the LTMH group showed t=2.105,P=0.037,which was statistically significant(P<0.05).6.The total effective rate of the treatment group after treatment was 88%,and the total effective rate of the control group was 43%.Conclusion: Corneal oxygen therapy combined with Chinese medicine ultrasonic atomization treatment of moderate to severe dry eyes can effectively improve the subjective symptoms of patients,delay the first and average tear film rupture time,and increase tears He is highly effective than conventional sodium hyaluronate eye drops.