| Objectve:China is a high incidence area of chronic HBV infection,accounting tor 1/3 of the total number of chronic HBV infection in the world.Chronic hepatitis b recurrent activity is the main factor leading to the progression of cirrhosis,and post-hepatitis b cirhosis is the main component of cirhosis in China.Control of HBV vinus replication and progress of ant-fibrosis are the main means to treat hepatitis b cirrhosis at present.Modern pharmacological studies have proved that Chinese herbal medicine has a clear ant-fibrosis effect.The main purpose of this study was to observe the clinical efficacy of yiqi jiedu tongluo prescription combined with wester medicine in the decompensation stage of hepatitis b cirhosis.Methods:a retrospective study was conducted on patients with Decompensated hepatitis b cirrhosis who Misited the infectious diseases department and gastroenterology department of dongzhirmen hospital from 2017 to 2019.According to whether receive yiqi jiedu tongluo prescription patients were divided into treatment group and control group.In the control group,63 Cases were treated by western medicine alone,while in the treatrent group,61 cases were treated by western medicine+yiqi detoxification tongluo prescription.Changes in total score of TCM symptoms,changes in TCM symptoms,changes in liver function,changes in blood coagulation,changes in platelets and changes inliver imaging indexes at the time of initial diagnosis.3 months and 6 months were Observed,and the results were evaluated.Sps517.0 Software was used for statistical processing.Results:(1)comprehensNve efficacy:the efective rate in the treatmnent group was 70%,and that in the control group was 29%.(2)symptoms and signs of traditional Chinese medicine:compared with before treatrnent,both groups could significantly improve the fuillness or pain in the thoracic cavity,lile appetite.bad breath,insomnia/dreaminess,itchy skin,dry eyes,and dull complexion(P<0.01).The treatment group was superior to the control group in improving the symptoms of fatigue and defecation(P<0.01,P<0.05)There was no significant improvement in the treatment group(P>0.05).However the control group had no improvement in the symptoms of urine yellow,head and body heavy,constipation,body and eye yellow and skin nail fault.(3):total score of TCM syndromes:after treatment.the total score of TCM in the two groups decreased significantly,while that of the treatrent group was significantly better than that of the sontrol group(P>0.01).(4)liver function:at 3 and 6 months of treatment,the liver function indexes of both groups were significantly imnproved,and at 3 months of treatrent,TBIL,GGT,ALT and A/G were superior to the control group.The curative effect of liver function indexes in the treatment group was better than that in the control group in 6 months.(5)hemagglutination at 3 and 6 rnonths of treatment:PT and PTA were significantly improved in both groups.The treatment group in March was better than the control group in PT,and the treatrnent group in June was better than the control group in PT andPTA.(6)PLT:after treatment for 3 and 6 months,both groups showed significant irnprovement in PLT,and the treatment group was better than the cortrol group.(7)ultrasound obseration indicators:there was no statistical diference in portal vein dlameter and splenic vein diameter between the two groups afte treatrment for 3 months and 6 months.indicating that the two groups showed no signlficant improvement in portal vein diameter and splenic yein diameter at the end of treatment for 6 months.The stabe ultrasound morphology of the two groups indicated that the two groups played a certain role in delaying the progress of the disease,which may also be caused by the long course of the disease and short observatior and treatment time Adverse reactions(8)Untoward effect:treatment of 2 cases appeared in the process of thin watery stool,number increase,clinical test results without exception,alleviate by oneself,after considering the adjustment in the process of detoxification reaction of gastrointestinal tract,1 case of patients after medicine dizzy,measuring blood pressure without exception,lay down to rest after the relief no recurrence after considering pathogenic factors in mnedicine to strive for good and evil.Conclusion:The clinical effect of yiqi jiedu tongluo on decompensation of hepatitis bcirrhosis is clear.It can obviously improve the TCM symptoms,symptoms and signs of patients.Yiqi jiedu tongluo prescription for the improvement of the laboratory index is also better than the simple western treatment.The decrease of portal vein diameter and splenic vein diameter was not different from that of the control group,which may also be caused by the shorter observation and treatment time. |
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