| Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by memory and cognitive loss, the formation of senile plaques containing amyloid-beta (Abeta) peptides, degeneration of the cholinergic neurons and the development of neurofibrillary tangles in the brains of the affected people.1 It is estimate that 5.1 million people in the United States are suffering from AD. The total annual care cost associated with AD is more than ;In this study, modified gold nanoparticles were used as a pseudo stationary phase in a capillary electrochromatography technique. An asymmetric disulfide synthesized from mercaptoundecanoic acid and dodecanethiol was chemisorbed onto 10 nm gold nanoparticles to form the pseudo stationary phase. With the help of the gold nanoparticle pseudo stationary phase, the separation of two Alzheimer's disease biomarkers namely; amyloid beta 40 and amyloid beta 42 was accomplished. This study demonstrates that the presence of modified gold nanoparticles in capillary electrochromatography can greatly influence the separation of amyloid beta peptides. |
