| Microwave ovens have transitioned from useful household appliances to new instrument used widely in the field of research. Additionally, microwave-based reactions are considered as a clean, fast method for synthesizing organic compounds in excellent yields. Therefore, in comparison to conventional heating, microwave heating has been proven to be more efficient and environmentally friendly.;In our continuous studies on the use of microwave heating for preparing heterocyclic compounds, I report the preparation of a series of 5-nitro-2-aminobenzo-[ b]thiophenes, benzoisothiozoles and benzoisoselenazoles. My interest in these heterocycles is due to their biological activities and use in drug discovery. First, I will discuss briefly an introduction into the history of microwave-assisted synthesis, followed by theory and various microwave reaction conditions. A brief introduction of the synthesized heterocyclic compounds using microwave radiation is discussed followed by results and discussion. All the products synthesized were characterized by 1H NMR and 13C NMR spectroscopy and Gas Chromatography/Mass Spectrometry. |
