| In recent years, Near Infrared Spectroscopy (NIRS) has gained wide acceptance in pharmaceutical industry. The growing interest in NIR is due to all the advantages that this powerful analytical technique presents. NIR spectroscopy is nondestructive, requires little or no sample preparation, does not require chemicals, solvents and generate little or no waste. The technique is also, simple, fast, and allows for multivariate analysis.; NIRS have become a useful analytical tool to develop a system capable of performing non-destructive analysis of drug content for an on-line testing of compressed tablets from a pharmaceutical batch. Analyzing just a fraction of the sample, thus eliminating the need to analyze instead of the entire sample, as in case of HPLC or UV analysis is it best attractive.; To explore the merits of NIRS for process control, an on-line drug system was constructed and NIR diffuse reflectance spectra were obtained with a diode array spectrometer that monitors the transport of up to 200 tablets per minute, carried in a stabilized conveyor belt. Ninety tablets with prepared at levels of 1% - 30% (w/w) of Active Pharmaceutical Ingredient (API). The wavelength used in the calibration models was 1645-1863 nm, corresponding to the API of the tablets, although others spectral regions associated with the majority excipients ingredients were also evaluated. Calibration models were constructed using several types of pretreatments to the data for the determination of drug content of the moving tablets, obtaining better results with PLS/SNV using two factors describing a 98.5% of variation with a RSEC of 7.3% and a RSEP of 6.5%. |
