| The unique properties of boron compounds, including electron deficient bonding, resistance to acid decomposition, and thermal stability, have lead to applications in medicinal chemistry, materials chemistry, and polymer chemistry. An important application of boron cluster compounds is Boron Neutron Capture Therapy (BNCT) for the treatment of cancer. Clinical success of BNCT requires compounds to be non-toxic, water-soluble, tumor targeting, and incorporate a large number of boron atoms. Combining substituted closo-carboranes with cycloadditon reactions such as the Huisgen 1,3-cycloaddition of terminal alkynes and azides is an efficient route to potential BNCT agents. Reactions of a variety of substituted closo-icosahedral carboranes with inorganic and organic azides were investigated to determine their utility in the synthesis of functionalized carboranes. The carboranes in this study interacted differently with organic verses inorganic azides. |
