Total Synthesis of the Polyketide Natural Product (-)-Pironetin and Studies Directed Toward the Total Synthesis of Iriomoteolide 1a
Posted on:2012-11-17
Degree:Ph.D
Type:Thesis
University:The University of North Carolina at Chapel Hill
Candidate:Dechert Schmitt, Anne-Marie Roe
Full Text:PDF
GTID:2451390008997231
Subject:Chemistry
Abstract/Summary:
Polyketides are secondary metabolites with diverse structural scaffolds. The research summarized herein describes the biomimetic total synthesis of the polyketide (-)-pironetin utilizing iterative aldol additions of thiazolidinethiones to create five of the six total stereocenters of (-)-pironetin. This technology has also been applied to a convergent synthesis to the core of the polyketide iriomoteolide 1a.