| Diabetes is a disease that has drawn much attention in recent years. Monitoring the status of diabetes is very important for proper treatment. Currently, the methods used involve invasive blood tests. However, the markers of diabetes are found not only in blood, but in saliva as well. By sensing these markers on a nanowire biosensor, it would be possible to create a much more comfortable solution to blood tests. This Thesis serves as an early feasibility study towards this end. In this study, we have first developed a feasible sensing protocol to test protein-antibody binding, sample delivery to sensors, and detection process. We then demonstrated successful detection of glycated albumin and glycosylated hemoglobin first in buffer solutions down to femtomolar concentrations. Monotonic increase of sensor signal is correlated with increasing protein concentrations. This study paved a way for our future work to test these diabetes markers in saliva. |
