| Osteoblasts and osteoblast precursor cells (mesenchymal stem cells) respond to the surface topography of metal implants by aligning along surface features in order to minimize shear stress. This study assessed the attachment, proliferation, and differentiation of human adult mesenchymal stem cells (hAMSC) on he depressions and peaks of CMOS sensors as a preliminary means of selecting surface topographies that might promote the greatest bone in-growth in vivo and therefore display the greatest osteoconductive properties. Although the specific topography (depressions, peaks, or the combination topography with both depressions and peaks) had no impact on the amount of calcium deposited on CMOS sensors, there was a significantly greater amount of calcium deposited on topographies with an etch depth of 15mum when compared to the same topography with an etch depth of 6mum. (Abstract shortened by UMI.)... |
