Cascade radical cyclization: Application in the development of new anticancer drug of camptothecin family and development of new synthetic method | Posted on:2003-06-07 | Degree:Ph.D | Type:Thesis | University:University of Pittsburgh | Candidate:Du, Wu | Full Text:PDF | GTID:2461390011989231 | Subject:Chemistry | Abstract/Summary: | | This dissertation presents synthetic studies on new anticancer drug of camptothecin family and development of a new cascade radical reaction as a novel synthetic method. Camptothecin is a prominent lead for anticancer drug development. The synthetic studies on camptothecin include: semi-synthesis of silatecan and drug candidate DB-67 by silyl radical addition, synthesis of homosilatecans and asymmetric synthesis of homocamptothecins, total synthesis of novel E-ring analog, development of a palladium promoted cascade reaction of isonitrile and its application in synthesis of drug candidates DB-67 and DB-91. The last chapter describes the development of a new cascade radical cyclization reaction of thiocarbamates, thoamides and thiourea. The new radical reaction provides a novel approach to cyclopenta-fused quinoline structures such as furoquinolines and indoloquinolines. | Keywords/Search Tags: | Radical, New anticancer drug, Development, Synthetic | | Related items |
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