| Membrane-bound nucleoside transport processes and their inhibitors regulate intra- and extra-cellular levels of endogenous D-adenosine and the actions of adenosine are mediated through adenosine receptors. Our research involved (1) developing a method to measure adenosine transport and release in animal cells and CNS tissue, (2) characterizing the transport processes involved, and (3) determining the effects of transport inhibitors on these processes. Using rat brain synaptosomal preparations we showed that (... |
