Structure-function relationships in conformationally biased decapeptide agonists of human C5a anaphylatoxin

Peptide synthesis, structure-function analysis, NMR spectroscopy, and molecular modeling techniques were used to characterize the structural features important for the biological activity of conformationally constrained decapeptide agonists of human C5a. These are the first studies to relate defined structural features in C5a agonists to specific biological activities. From a panel of conformationally constrained agonists, the two most potent agonists, YSFKDMPLaR (C5a...