| Implantable biomaterial made from austenitic 316L stainless steel have been widely used in a variety of clinical applications. However, exposure of foreign surfaces to blood can initiate platelet adhesion and trigger blood coagulation, leading to life-threatening consequences. In order to prevent undesirable surface platelet adhesion, we have developed an ultrathin anti-thrombogenic coating based on monoethylene glycol (MEG-OH) silane chemistry. Surface characterization of major surface modification steps are done by X-ray photoelectron spectroscopy and supplemented with contact angle goniometry. End stage anti-thrombogenicity assessment after 20 min blood exposure at 100 s-1 , 300 s-1 , 600 s -1 , 750 s-1 , and 900 s-1 shear rate has shown significant reduction (> 90%) of platelet adhesion, aggregation and thrombus formation on MEG-OH surface modified 316L stainless steel, compared with untreated ones. This finding is confirmed by real-time surface evaluation of 60 min blood exposure at 100 s-1, 600 s -1, and 900 s-1 shear rate. |
