Synthesis and Characterization of Thiophene Fused Pyridine Heterocycles Derivative

In organic chemistry, bicyclic compounds in which the two rings share two adjacent at-oms or a covalent bond are called fused ring systems. Thiophene fused pyridine systems are one important class of heterocyclic compounds. They attract considerable interest because of their great practical usefulness, primarily due to their biological activities. Thienopyridines, which are a class of drug targeting the platelet adenosine diphosphate (ADP) 2 receptor, demonstrate the im-portance of this class of compounds.;Our objective is to look for a simple method for the synthesis of thiophene fused pyridine heterocycles. In our research, a multicomponent reaction was explored by reacting an aldehyde with malononitrile and NaSH in the presence of a base producing an intermediate 2-amino-3,5-dicyano-6-mercaptopyridine, which is the precursor for synthesis of the final product thiophene fused pyridines. It then undergoes alkylation and cyclization reactions after treatment with alpha-halogen compounds in presence of sodium alkoxide as base catalyst. The products were synthe-sized in excellent yields and were analyzed by IR, 1H NMR and 13C NMR spectroscopy.