Oligonucleotide-directed cleavage of single- and double-stranded DNA by double and triple helix formation

Posted on:1991-08-02

Degree:Ph.D

Type:Thesis

University:California Institute of Technology

Candidate:Griffin, Linda Chu-Li

Full Text:PDF

GTID:2471390017951934

Subject:Biology

Abstract/Summary:

art I. Single-stranded cleavage. The machine synthesis of a DNA hybridization probe 19-nucleotides in length, equipped with the metal chelator EDTA has the sequence 5;Part II. Double-stranded cleavage. Oligonucleotide recognition offers a powerful chemical approach for the sequence-specific binding of double helical DNA. In the pyrimidine-Hoogsteen model, a binding site size of...

Keywords/Search Tags:

Cleavage

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