Tandem Diels-Alder/Nazarov Reaction of Ynones and Diynone

The Chalifoux group's interest is in exploring new synthetic methodologies that lead us to achieve a diverse array of complex products in fewer steps. We interested in the reactivity of ynones for the purpose of probing new methodologies toward synthesizing biologically active molecules via tandem reaction processes.;The synthesis of cyclic molecules remains an important aspect of organic synthesis due to their presence in a variety of natural and synthetic chemicals. There is a number of ways to construct cyclic structures that contain 5- and 6-membered rings with the Nazarov and Diels-Alder reaction being one of the most powerful methods, respectively.;Our approach is to develop new and efficient methods to synthesize fused five and six-membered polycyclic ring systems comprise the basic structure for a large number of important biologically active molecules through the use of multicomponent and/or tandem Diels-Alder/Nazarov cyclization of beta-silyl substituted aryl ynones to generate carbo- and heterocyclic fused ring systems.