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Protein engineering and structure/function analysis of a diphtheria toxin-related interleukin-2 fusion toxin

Posted on:1991-12-24Degree:Ph.DType:Thesis
University:Boston UniversityCandidate:Williams, Diane PlatoniotisFull Text:PDF
GTID:2474390017952395Subject:Biology
Abstract/Summary:
Diphtheria toxin (DT) is a 535 amino acid protein that inhibits protein synthesis by catalyzing the adenosine 5;A human IL-2 gene was synthesized in vitro, and its 5;The DT-related IL-2 fusion gene was constructed such that Pro;Cassette exchange and deletion mutagenesis were used to explore structure/function relationships of DAB...
Keywords/Search Tags:Protein
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