| Experimental data on perchloroethylene (PCE) induced hepatocarcinoma in male B6C3F1 mice and male Fischer rats are analyzed using pharmacokinetic and oncogenic models. The data are found to be consistent with the hypothesis that PCE-induced hepatocarcinomas result from the chemically induced promotion of spontaneously occurring preneoplastic liver cells. The methodology used in this study would be useful for removing the uncertainties involved in the quantitative risk assessment of carcinogens arising from the use of animal cancer data for the prediction of human cancer risk. |
