Role Of Hub Genes And Branch-chain Amino Acid Metabolism In Breast Cancer Development Based On Bioinformatics Analysis

Breast cancer(BC)is the most frequently diagnosed cancer and is also the leading cause of cancer death among females in the most of countries.Therefore,it is of great significance to investigate the molecular mechanism of the occurrence and development of breast cancer for the discovery of therapeutic and prognostic targets.A variety of genetic changes has been implicated in the development of breast cancer.However,the molecular mechanisms of BC are not fully understood.Therefore,identifying key genes involved in tumorigenesis and progression of breast cancer can help to understand the underlying mechanism of breast cancer and find more therapeutic and diagnostic targets.We performed an integrative bioinformatics method to screen hub genes.These hub genes are highly associated with cell division and cell cycle.Metabolic reprogramming is considered as one of the characteristics of cancer,which is related to the cancer development.We found that BCAA metabolic reprogramming was closely related to the development of breast cancer.However,the underlying mechanisms between BCAA metabolic reprogramming and breast cancer remain unkown and needs further exploration.We found that BCAA can promote tumor apoptosis by anti-tumor immunity.We also found that low BCAA can promote the metastasis of breast cancer by enchancing epithelial-mesenchymal transition(EMT).Therefore,BCAA metabolism is expected to become an important target for the treatment of breast cancer,providing a new orientation for the treatment of breast cancer.