Effects Of Antimony On Viability And Fecundity Of Musca Domestica

Antimony(Sb)is a kind of semi-metallic element,which is a non-essential element for life processes.As a result of extensive mining and industrial activities,the amount of antimony in the environment is increasing,but its toxic effect on organisms have not been systematically assessed.In addition,China is the country with the highest production and use of antimony in the world,and the environmental and health risks caused by antimony pollution need to be discussed in depth.The purpose of this study,which uses the Musca domestica as experimental material,systematically investigated the toxic effects and underlying mechanisms of antimony exposure on organisms,focusing on the changes in growth,development,reproductive capacity and mitochondrial function of M.domestica.In this study,M.domestica were exposed to Sb(V)at different concentrations in the environment for stress experiments from the egg stage to adult stage.Using classical toxicology,biochemistry and modern molecular biology techniques,we comprehensively studied the effects of antimony exposure on the growth,development,physiology,biochemical and reproductive capacity of M.domestica.By exploring the toxic effects and potential mechanisms of antimony,the following research results were obtained:1.Antimony exposure resulted in decreased viability of M.domestica,including weight loss,reduced body length,delayed development,developmental deformities and reduced survival rate.2.Antimony exposure can induce oxidative stress reaction in the vivo of M.domestica,causing intestinal damage and mitochondrial dysfunction,damaging the processes of nutrient absorption and energy supply,and ultimately causing the decline of the motor ability of M.domestica.3.Antimony exposure led to decreased in the reproductive capacity of M.domestica,which was characterized by ovarian dysplasia and DNA damage,follicular retardation,reduced survival rate of the offspring generation,and disrupts the expression of several key genes in the reproductive signaling pathway.In conclusion,antimony can inhibit the growth and development of M.domestica,and damage its reproductive ability,thus reducing the viability of M.domestica.This paper can provide abundant data for the study of the toxic effects and mechanisms of antimony,provide scientific basis for the assessment of environmental and health risks exposed to antimony,and also provide reference for the study of human health toxicity caused by antimony.