Finite Element Analysis Of Mechanical Properties Of Red Blood Cells Based On Neural Network

Human healthy red blood cells have strong deformability.However,in the process of storage,the damage of structural components of red blood cells gradually accumulates,leading to the change of their morphology,the loss of smooth double concave shape and the formation of acicular body,which reduces the deformability and mechanical properties of red blood cells.Therefore,it is one of the key topics in the field of biomechanics to study the mechanical properties of biconcave red blood cells and acanthocytes I and reveal their deformation mechanism.In this paper,the normal biconcave red blood cells of human beings and the red blood cells(acanthocytes I)that initially appeared in the storage process were taken as the research objects,and the constitutive parameters of cell membrane were predicted based on a variety of hyperelastic material constitutive models and neural network,and the constitutive parameters of cell membrane hyperelastic material were obtained,mainly including the following aspects:(1)A three-dimensional finite element model of biconcave red blood cells and acanthocyte I was established.A neural network model for predicting the parameters of red blood cell hyperelastic materials is established.According to the characteristics of the diameter of red blood cell stretched by optical tweezers as a function of the stretching force,the mapping relationship between the material parameters and the stretching force of optical tweezers is established.The materials corresponding to the three different hyperelastic constitutive models of cell membrane in Neo-Hookean?Mooney-Rivlin and Reduced Polynominal are predicted Parameters.(2)Based on three different hyperelastic constitutive models,the predicted material parameters are applied to the finite element analysis of the stretching process of biconcave red blood cells and acanthocytes I optical tweezers,and the appropriate constitutive model is found by comparing the experimental results.The influence of constitutive model on the deformation characteristics of red blood cells is explored,and the stress components of biconcave red blood cells and acanthocytes I in the stretching process of optical tweezers are obtained The correctness of the finite element analysis,the neural network model and the prediction results are verified by comparing the results of the finite element analysis with the experimental results(3)A three-dimensional finite element model of red blood cells indented by AFM is established.Based on the above three kinds of hyperelastic constitutive models and predicted constitutive parameters,the process of normal double concave red blood cells indented by indenter with different diameters is simulated by finite element method,and the results of simulation and analysis are compared with the experimental results,which further verifies the prediction results of the neural network model correctness.