Study On Radiation Dose And Temperature Control Of Cell Sample In 900 MHz Electromagnetic Resonator

With the emergence of various electronic devices,organisms are exposed to more and more electromagnetic radiation,and the biological effects that electromagnetic radiation may cause have gradually attracted people's attention,especially the influence of non-thermal effects.In order to prevent possible harm from biological effects in advance,it is necessary to carry out relevant biological experiments to obtain relevant predictions.Non-thermal effects can directly reveal the biological basis and molecular mechanisms of electromagnetic radiation,such as the site of action of electromagnetic fields on cells and the molecular pathways of the effects.The common method for studying non-thermal effects is to increase the radiation dose.The disadvantage is that as the radiation dose increases,the interference of the thermal effect also increases.The current cell irradiation experiment system cannot effectively increase the irradiation dose,resulting in the inability to effectively detect nonthermal effects.This article mainly conducts research from two aspects: first,based on the 900 MHz electromagnetic model to optimize the radiation dose;second,based on the biological heat conduction equation to analyze the temperature change of the temperature model,study how to control the ambient temperature,and propose and optimize the adaptive Temperature control method.According to the FDTD method,an accurate cell sample model and a simple resonant cavity model were constructed,and the radiation dose of the cell sample was analyzed using the relevant knowledge of biodosimetry.Place the cell sample inside the resonant cavity for electromagnetic simulation,optimize the irradiation efficiency and unevenness of irradiation,obtain the optimal irradiation dose,confirm the electromagnetic model structure of the irradiation experiment system,and finally obtain an irradiation efficiency of 15.62%,The irradiation unevenness is 28.83%,which meets the requirements of the cell irradiation experiment.Designed and built a cell irradiation experiment system,including a resonant cavity module,a power source module,and a temperature control module.According to the SAR distribution of electromagnetic simulation,the temperature model of the cell sample and the scaffold is constructed,and the temperature change is analyzed by the biological heat conduction equation,and an adaptive temperature control method is proposed: controlling the environmental temperature drop to compensate for the temperature increase of the cell monolayer caused by irradiation.An exponential temperature control method is analyzed.Its shortcoming is that the value of the time constant must be accurate.Then an iterative temperature control method is proposed and the cell temperature changes under different irradiation doses are analyzed.Within the thermal effect threshold,the theoretically achievable maximum radiation dose is 2.7 times that of the traditional constant temperature radiation system,but limited by the accuracy of the temperature control module,the allowable radiation dose for the cell radiation experiment cannot be higher than the maximum radiation dose.90% of the radiation dose is still 2.4 times that of the traditional constant temperature radiation system,which can achieve non-thermal effects at radiation doses three times the safety threshold.