Applied Research And Synthesis Of Macrocyclic Amide Metal Complexes

The macrocyclic polyamides are excellent organic ligands with unique structure.They have strong tendency to bind with transition metal ions,therefore to form metal complexes.Macrocyclic polyamido metal complexes have various properties and are widely used in the fields of chemistry,biology and medicine.Thus,it has profound significance to further explore the synthesis and expand the application of thses metal complexes.Four species of transition metal coordination compounds,five ligands and several key intermediates were synthesized from 3,4-diaminopyridine,2-aminoisobutyric acid,oxalyl chloride,dimethylmalonyl dichloride and transition metallic salt via amidation reaction in three steps.Meanwhile,the influence of reactive temperature,time,solvent,materials adding order and ratio were studied to optimize reaction route.The structures of products were characterized by nuclear mafnetic resonance,mass spectra and infrared spectroscopy ect.It was found that four-amino macrocyclic ligands metal complexes could be obtained from 3,4-diaminopyridine,dimethyl propylene amide diacid and ferric trichloride via one-step process,and the yield could be up to 46.3%.The reaction route was also optimized.Furthermore,the properties of the compounds were investigated.In this text,we chose 4 kinds of dyes from cationic dyes and investigated the treatment efficiency under the best reaction condition.The results showed that the removal of color were greater than 70%.The removal of TOC and COD of CI basic red 46 were all the best and they were greater than 40%.After the treatment by catalyst,BOD₅/COD of C.I.basic red 46,which presents the highest removal efficiency,increased to 0.368 from 0.084.By contrast,BOD₅/COD of C.I.basic blue,which presents the lowest removal efficiency,increased to 0.269from 0.073.It will be beneficial for the following biological treatment.