Study On The Activation Of Quinolone And The Allyl Migration Cyclization Reaction

Oxygen and nitrogen heterocyclic compounds has received widespread attention in the synthesis of organic molecules and natural products,they have good biological activity and pharmacological value.At the same time,allyl structure plays an important role in medicine,molecular synthesis of biologically active natural products and molecular materials.This paper mainly of allyl migration,cyclization and N-allyl quinolone compounds activation reaction to explore,divided into the following five parts:Firstly,the migration and the cyclization of the allyl molecule have a very wide range of signif icance in the synthesis of drug molecules,especially in the synthesis of nitrogen and oxygen heterocyclic compounds.In this section,we have made a wealth of research on the migration of the vinyl group and the reaction of the.Secondly,quinolone compounds are belonged to flavonoids nitrogen heterocyclic compounds,the pyranoquinoline is containing nitrogen and oxygen heterocycles active drug structure.In the past period of time,quinolone compounds and pyranoquinoline derivatives in anti allergic activity and anti bacteria activity has a very good role,there are a lot of research in this area.In this section,we summarize the research progress of quinolone derivatives,and pyranoquinoline compounds synthesized.Thirdly,There are many literatures reported about quinolone halogenation reaction.Most have chosen CCl₄ or POCl₃ the toxicity of relatively large reagent to promote this reaction.In the section we first choice of KI and 2,2'-bipyridine coordination to promote the reaction,KI in response not noly to the catalyst role,but also for iodination reaction with iodine source,mild reaction conditions,simple raw materials,process does not involve expensive metal.Next,The extension of allyl on nitrogen and oxygen heterocyclic compounds and its important role in the synthesis of drug molecules,we use transition metal palladium catalyzed the N-allyl quinolone compounds occur allylic migration and cyclization reaction pyranoquinoline derivatives reaction to explore.During the exper iment not only to explore the allyl migration,cyclization in one step of the simple method,also have obtained the bioactive pyranoquinoline drug molecules.Finally,the allyl can effectively extend nitrogen and oxygen heterocyclic compounds,expanded the scope of the compounds.we choose to the allyl benzoate as the starting material,in BF₃.OEt₂,Ph I(OAc)₂ and acetic acid under the action of synthetic(2-phenyl-1,3-dioxol-4-yl)-methyl acetate derivatives which is containing the dioxolane ring skeleton.Luckily,in BF₃.OEt₂,the acetyl of acetic acid was successfully coupled to the product molecules and provide a new and effective method for the synthesis of drug molecules.