Research On Copper-catalyzed The Synthesis Of Substituted Pyrrolo[1,2-a] Quinoxalines

Quinoxaline and its derivatives are important class of nitrogen-containing heterocyclic compounds,which widely exist in many natural compounds.Pyrrolo[1,2-a]quinoxaline and its derivatives have excellent biological activities such as anticancer and anti-toxicity.Therefore,to synthesize special materials and new drugs containing pyrrolo[1,2-a]quinoxaline structure core according to these properties,or to find more simple,environmental friendly and efficient synthesis path of pyrrolo[1,2-a]quinoxaline compounds is concerned by researchers.In this study,the new progress of pyrrolo[1,2-a]quinoxaline and its derivatives in the field of application and synthesis methods is introduced in detail,and a new path of substituted pyrrolo[1,2-a]quinoxaline compounds catalyzed by copper is introduced.The research contents are mainly composed of the following three parts:Part ?:The application and synthesis progress of pyrrolo[1,2-a]quinoxaline is reviewed.Pyrrolo[1,2-a]quinoxaline compounds often have special biological activities and are widely used in the field of pharmaceutical synthesis.In this part,the application examples of pyrrolo[1,2-a]quinoxaline compounds in the field of medicine and biology in recent years are listed,and the synthesis methods of pyrrolo[1,2-a]quinoxaline compounds in recent years are summarized.Part ?:The new application of alkylboronic acid compounds in the field of synthesis is described.As an important raw material of coupling reaction,organic boronic acid compounds play an important role in the field of chemical synthesis,and a series of new applications of alkylboronic acid in the field of chemical synthesis in recent years is introduced.Part ?:A synthetic method of pyrrolo[1,2-a]quinoxaline is studied.A method for the synthesis of pyrrolo[1,2-a]quinoxaline compounds is introduced in detail,that is the ring formation of 1-(2-aminophenyl)pyrrole with Cu(OPiv)₂ as catalyst,In this reaction,1-(2-aminophenyl)pyrrole reacts with alkylboronic acid via a free radical process under O₂ as oxidant to form the target product.The reaction conditions are mild,environmental friendly,good substrate compatibility and high yield,which provides a method for the rapid and efficient construction of pyrrolo[1,2-a]quinoxaline compounds under simple conditions.