Reaction Research Of Ynamides Synthesis And Related Gold Catalysis In Abietic Acid Based Surfactant-Water

With the shortage of petroleum resources in China,the development and utilization of renewable biomass resources have attracted extensive attention.Rosin is a typical biomass resource and the output of rosin in China has always ranked first in the world.But rosin has always been used in papermaking,printing ink,coating,rubber,adhesive,food additive and biological products after simple processing in the form of a mixture.And the deep processing product of rosin needs to be imported from abroad mostly Therefore,China is faced with the embarrassing situation of high rosin production but low rosin deep-processed products resulting in low added value of rosin.In addition,in organic synthesis,traditional synthesis methods of Ynamides use organic solvents as the reaction medium.The extensive use of organic solvents leads to serious environmental pollution problems,which does not meet the"green chemistry"concept.In addition,there are currently many methods for synthesizing furan derivatives,but there are few methods for synthesizing amine-substituted furan derivatives.In order to alleviate the problem of fewer rosin deep-processed products in China,this paper modified the main component of rosin,abietic acid,and prepared a nonionic surfactant APGS-2000-M.For the environmentally friendly synthesis of Ynamides,this paper prepared APGS-2000-M as a solution and used it as the solvent for copper-catalyzed coupling synthesis of Ynamides.In order to make the synthesis of amine-substituted furan derivatives more convenient,this paper developed a gold-catalyzed reaction of Ynamides with allyl alcohol to synthesize amine-substituted furan derivatives.First,this paper prepared the surfactant APGS-2000-M with abietic acid as the raw material,and formulated it into an aqueous solution with a mass fraction of 2%.Then the APGS-2000-M aqueous solution was used instead of the organic solvent in the classic copper-catalyzed dibromoolefin amidation reaction,and the reaction conditions were optimized.The optimal reaction condition was 10 mol%Cu SO₄·5H₂O,20 mol%DMEDA,KOH(4 equiv),2 wt%APGS-2000-M H2O(0.5 M),reaction temperature 60?,reaction time 8 h.Under the optimal conditions,28 Ynamides were synthesized with a yield of 45-95%.Finally,a method of synthesizing amine-substituted furan using diacetylenamide as a raw material and a gold-catalyzed strategy was developed.The feasibility,product structure,and mechanism verification of the method were studied,and certain progress was made.The research content of this paper provides a new strategy for the preparation of rosin deep-processed products,improves the added value of rosin,and expands the application range of rosin;at the same time,it realizes a new method for the synthesis of Ynamides by the Copper catalyzed amination of dibromoalkene in aqueous solution.The development of green chemistry has promoted.Finally,it provides a new method for the synthesis of furan derivatives,which promotes the development of furan drugs and natural products to a certain extent,and has certain guiding significance for the theoretical research of gold catalysis.