Synthesis Of Heterocyclic Compounds Containing Nitrogen And Trifluorometh-Ylsubstituted Enamine Compounds

Nitrogen heterocyclic compounds are an important class of bioactive molecules.Studying their chemistry helps people understand their role in living organisms.Therefore,the synthesis of such compounds is of great significance and value.Pyrrole,a particularly important branch of organic nitrogen heterocyclic compounds,plays a very important role in organic chemistry.Pyrrole is an important class of heterocyclic compounds with biological activity and pharmacological significance.A large number of structurally diverse pyrrole,pyrrole and pyrrole alkaloids are known as alkaloids.Indoles are the most abundant heterocyclic compounds in bioactive natural products and pesticides,and they also have related structures in functional materials.Indoles are one of the most abundant systems in nature and also important heterocyclic compounds.Due to its unique properties,fluorine has different properties in different fields.From surfactants,polymers,materials to pesticide and other pharmaceutical ingredients,its shadow can be seen with a familiar look.Because of its excellent biological activity,SCF₃ stands out from other fluorinated functional groups.Based on the reference of literature,this paper mainly focuses on the following work:The first chapter,A brief review of pyrrole compounds,1,1-enylenediamine,indole derivatives,and trifluoromethylsulfide reactions is presented.The second chapter,I developed a simple and efficient method to synthesize a series of pyrrole compounds by using 1,1-endiamine and hexanaldehyde as raw materials,ethanol as solvent and reaction at room temperature for four hours.In the third chapter,an experimental method for the synthesis of indoles from tetrafluoro-p-phenyldinitrile and pyridine ester compounds was established.The reaction condition was acetonitrile as solvent and triethylamine as catalyst,and reflux reaction was conducted for 20 hours.In the fourth chapter,the synthesis of enolamine trifluoromethasulfide compounds was completed.I designed such a reaction route:N-trifluoromethasulfide saccharin and enamine compounds were used as raw materials,the solvent was ionic liquid,and the target compound could be obtained after half an hour of reaction at room temperature.