Preparation Of Bi Metal Nanoparticles With Low Melting Point And Study On Their Novel Response Properties

With the trend of economic globalization,people’s life pressure is increasing,the incidence of various diseases is increasing,the threat of diseases to people’s health is gradually raising,and people’s requirements for therapeutic effects are becoming higher and higher.Therefore,the scientific research personnel’s investment in biomedical research is also getting more and more in-depth.In recent years,a large number of studies have shown that the therapeutic effect of metal nanoparticles in biomedicine is very prominent,and the research and application of near infrared light in medicine is also very wide.For example,near infrared light is involved in the treatment of cancer,sterilization,medical aesthetics,etc.The main reason is that near-infrared light has strong tissue penetration ability,less damage to normal tissue cells,and has the advantages of low side effects,high efficiency,and accuracy.Therefore,the combination of this method and metal nanoparticles has become a New research directions for medical treatment.In this paper,bismuth nanoparticles with high purity,small particle size and stable properties were successfully designed and synthesized by hydrothermal method,and modified by sodium polystyrene sulfonate to improve its physiological stability.Through the characterization and analysis of nanoparticles,The performance of its combination with photothermal therapy in the field of sterilization and drug release was studied.The photothermal heating experiment found that the bismuth nanoparticles exhibit a high photothermal conversion efficiency,which can reach40.9%.The solution stability and bacterial toxicity experiments show that the bismuth nanoparticles exhibit excellent physiological stability and physiological compatibility with low bacterial toxicity.The sterilization experiment of photothermal therapy was carried out using the high photothermal conversion efficiency of bismuth nanoparticles.The results showed that increasing the concentration of bismuth nanoparticles and prolonging the time of near infrared light could inhibit the growth and reproduction of E.coli and S.Guar has better biocompatibility and stability,and bismuth nanoparticles have higher photothermal conversion efficiency.Explore the effect of bismuth nanoparticle hydrogel composite material combined with guar gum on the release of drug molecules under the action of near infrared light.The analysis of the properties of guar gum showed that the release rate of methyl blue drug molecules was slower than rhodamine B drug molecules.