The Preparation Of Fe₃O₄@SiO₂ Msgnetic Nanoparticles

Fe₃O₄magnetic nanoparticles are a kind of functional materials with both traditional nano material properties and superparamagnetic properties.They play an important role in many different fields,such as purification and recognition of chemical biology and drug delivery of pharmaceutical chemistry.Due to the different surface modification materials and functional groups of Fe₃O₄magnetic nanoparticles,they have different properties.Among many surface modification materials and groups,SiO₂is one of the most common materials to modify Fe₃O₄magnetic nanoparticles.Through the modification of SiO₂,the mechanical strength and biocompatibility of magnetic nanoparticles can be improved,which promotes their performance in practical use.In recent years,magnetic nanoparticles have been gradually applied in the field of in vitro diagnosis.For example,magnetic nanoparticles are widely used as an important raw material in the detection of nucleic acids for novel coronavirus pneumonia.However,at present,the high-end products of the raw material mainly rely on imported products.Domestic Fe₃O₄magnetic nanoparticles have many problems,such as homogeneity,repeatability,batch stability and so on,which are difficult to meet the needs of the precision market and directly affect the accuracy of the final test results.This paper is mainly about the research on the laboratory scale-up process of Fe₃O₄@SiO₂magnetic nanoparticles.In this paper,Fe₃O₄magnetic nanoparticles were prepared by high temperature decomposition method and modified by SiO₂promoted by ultrasound.The specific experimental process is as follows:firstly,according to the relevant raw materials,such as anhydrous ferric chloride(Fe Cl₃),anhydrous sodium acetate(Na Ac)and anhydrous sodium citrate(Na₃CA),the different proportions of different raw materials and the quality requirements of raw materials are optimized to establish the best experimental conditions;then,the prepared magnetic nanoparticles were evaluated by a series of different chemical properties,and their performance in practical use was evaluated by nucleic acid extraction;finally,according to the demand of the market,the analysis of the preparation process of Fe₃O₄@SiO₂magnetic nanoparticles was optimized to improve the single batch production of magnetic nanoparticles to meet the market demand.Through the above optimization process,at present,Fe₃O₄@SiO₂The monthly production of magnetic nanoparticles can be used to configure 2 million person time detection reagents.