Study On Biodegradable Zn Mg Mn Alloy Vascular Stent

Coronary heart disease caused by cardiovascular stenosis is one of the main diseases endangering human life and health.In the treatment of coronary heart disease,interventional therapy has become the main method for the treatment of cardiovascular stenosis because of its small trauma and good effect.One of the core technologies of interventional therapy is the application of vascular stent.The research of stent materials is of great significance for the treatment of cardiovascular stenosis.Compared with traditional metal stents,biodegradable vascular stents have unique degradability,which can avoid permanent foreign bodies in the human body.Biodegradable stents include biodegradable polymer stents and biodegradable metal stents.In comparison,the mechanical properties and wall thickness of the latter are similar to those of the traditional permanent stent,and the adaptability and range are more extensive,which can be said to theoretically overcome the shortcomings of the permanent stent.The research significance and purpose of this project is to find a biodegradable metal alloy scaffold with excellent mechanical and physical properties,stable corrosion rate,good cell compatibility and no adverse reactions in vivo.The metal Zn Mg Mn alloy studied in this paper has the excellent comprehensive properties mentioned above,so we hope to demonstrate whether it can be implanted into the human body to complete the role of supporting blood vessels by studying the metal alloy material.In this paper,the mechanical and physical properties,corrosion,cell compatibility and in vivo of zn-0.1mg-0.2mn alloy metal materials are studied1.Study the mechanical properties of materials by studying the composition,hardness and microstructure of materials.After extrusion,the hardness of the material is 85.5hv,the grain size is 40 ?m,the strength is 296.6mpa and the elongation is26.6%.The overall physical and mechanical properties are good,in line with the current market for metal alloy stent mechanical properties requirements.2.The corrosion rate of the material in simulated body fluid is about 0.7 mg / cm2 * D.The results show that the corrosion appearance of the material is uniform corrosion,which meets the requirements of the current market for the corrosion rate and appearance of metal alloy support.3.The cytocompatibility of the material was studied by CCK-8 method.The cytotoxicity of the material was grade 1,which met the requirements of cytocompatibility of metal alloy scaffolds on the market.4.Through reading the experimental literature of biological scientists on metal alloy scaffolds in vivo,it is found that the materials have no effect on vivo.