Study On Electrochemical Synthesis Of Sulfonate Esters Compounds And Trifluoromethylation Reaction

Compared with traditional organic synthesis,organic electrochemical synthesis uses electron transfer to drive the reaction without the addition of oxidant,which has no pollution to the environment and conforms to the environmental protection concept of "green chemistry".In addition,organic electrochemical synthesis avoids the residual problem of transition metal without transition metal catalysis,which ensures the safety of drug synthesis.Therefore,organic electrochemistry has received increasing attention in recent years as a novel synthesis method.In this paper,the development history of organic electrochemistry has been briefly summarized.Around anodic oxidation strategy,it's expected to design the transformation without transition metal catalyst or external oxidant,in which the substrate is induced to be oxidized at the anode to synthesize desired product.It's noteworthy that sulfonates are not only a class of special bioactive drugs,but also important intermediates in the conversion,in addition,trifluoromethyl is also commonly found in drug molecules.The following two studies have been researched in-depth using electrochemical method through literature research and analysis:1.Efficient and green method to synthesize sulfonates under mild conditions has been developed in the absence of transition-metal catalyst and oxidant.2.Green trifluoromethylation of ortho C-H bond aromatic amides has been realized using cheap trifluoromethylation reagent as the source of trifluoromethyl.